This Thanko Speaker Mouse should keep your Skyping and VoIPing nice and clear. There’s a small speaker built into the top of the mouse and best of all it comes with a lapel mic so you won’t sound like you’re shouting at people from the other end of a cathedral. The mouse is 1000dpi and the kit works with Windows and Mac OS. ~US$32.
Thanko Speaker Mouse combine an USB 1000dpi mouse with a Speaker. A tie microphone is even included.